Synthesis and Characterization of Novel Oxadiazole and Pyrazole Hybrids as Potential Antimicrobial Agents
نویسندگان
چکیده
As a part of our ongoing research in the exploration of novel antimicrobial agents, we report herein novel synthesis of hybrid molecules 4-methyl-7-(2-oxo-2-(5-(substitutedthio)-1,3,4oxadiazol-2-yl)ethoxy)-2H-chromen-2-ones and 4-substitutedbenzylidene-3-methyl-1-(2-((4methyl-2-oxo-2H-chromen-7-yl)oxy)acetyl)-1H-pyrazol-5(4H)-ones by combining coumarin ring with 1,3,4-oxadiazole and pyrazole scaffolds respectively. All the synthesized compounds have been characterized by chemical analysis, IR, H NMR, C NMR and mass spectroscopy. All the compounds have been evaluated for their in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli and fungi Aspergillus niger using serial broth dilution method. All the synthesized compounds displayed antimicrobial activity. Among all the compounds 7c and 7d have been emerged as highly potent molecules with 75 μg/mL potency.
منابع مشابه
Synthesis, characterization, molecular docking studies and biological evaluation of some novel hybrids based on quinazolinone, benzofuran and imidazolium moieties as potential cytotoxic and antimicrobial agents
Objective(s): Hybridization of bioactive natural and synthetic compounds is one of the most promising novel approaches for the design of hit and lead compounds with new molecular structures. In this investigation, a series of novel hybrid structures bearing quinazolinone, benzofuran and imidazolium moieties were designed and synthesized. Materials and Methods:Novel hybrid compounds were prepare...
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